Uncertainty quantification for personalized analyses of human proximal femurs

Computational models for the personalized analysis of human femurs contain uncertainties in bone material properties and loads, which affect the simulation results. To quantify the influence we developed a probabilistic framework based on polynomial chaos (PC) that propagates stochastic input variables through any computational model. We considered a stochastic E-ρ relationship and a stochastic hip contact force, representing realistic variability of experimental data. Their influence on the prediction of principal strains (ϵ1 and ϵ3) was quantified for one human proximal femur, including sensitivity and reliability analysis. Large variabilities in the principal strain predictions were found in the cortical shell of the femoral neck, with coefficients of variation of Math Eq. Between 60-80% of the variance in ϵ1 and ϵ3 are attributable to the uncertainty in the E-ρ relationship, while Math Eq are caused by the load magnitude and 5-30% by the load direction. Principal strain directions were unaffected by material and loading uncertainties. The antero-superior and medial inferior sides of the neck exhibited the largest probabilities for tensile and compression failure, however all were very small (Math Eq). In summary, uncertainty quantification with PC has been demonstrated to efficiently and accurately describe the influence of very different stochastic inputs, which increases the credibility and explanatory power of personalized analyses of human proximal femurs

A Parallel High-Order Fictitious Domain Approach for Biomechanical Applications

The focus of this contribution is on the parallelization of the Finite Cell Method (FCM) applied for biomechanical simulations of human femur bones. The FCM is a high-order fictitious domain method that combines the simplicity of Cartesian grids with the beneficial properties of hierarchical approximation bases of higher order for an increased accuracy and reliablility of the simulation model. A pre-computation scheme for the numerically expensive parts of the finite cell model is presented that shifts a significant part of the analysis update to a setup phase of the simulation, thus increasing the update rate of linear analyses with time-varying geometry properties to a range that even allows user interactive simulations of high quality. Paralellization of both parts, the pre-computation of the model stiffness and the update phase of the simulation is simplified due to a simple and undeformed cell structure of the computation domain. A shared memory parallelized implementation of the method is presented and its performance is tested for a biomedical application of clinical relevance to demonstrate the applicability of the presented method